Published in
Royal Society of Chemistry, Lab on a Chip, 13(21), p. 2495-2510, 2021
DOI: 10.1039/d1lc00192b
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Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D in vitro platform
Journal article published in 2021 by
Saba Goodarzi 
,
Audrey Prunet,
Fabien Rossetti ,
Guillaume Bort ,
Olivier Tillement ,
Erika Porcel ,
Sandrine Lacombe,
Ting-Di Wu,
Jean-Luc Guerquin-Kern ,
Hélène Delanoë-Ayari ,
François Lux ,
Charlotte Rivière
,
Audrey Prunet,
Fabien Rossetti ,
Guillaume Bort ,
Olivier Tillement ,
Erika Porcel ,
Sandrine Lacombe,
Ting-Di Wu,
Jean-Luc Guerquin-Kern ,
Hélène Delanoë-Ayari ,
François Lux ,
Charlotte Rivière
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Abstract
We present a simple yet highly flexible 3D-model microsystem for the investigation of nanotherapeutics transport, ahead of in vivo studies, allowing to follow the penetration and distribution of nanoparticles within spheroids over space and time.