Published in
Royal Society of Chemistry, RSC Medicinal Chemistry, 5(12), p. 804-808, 2021
DOI: 10.1039/d1md00086a
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Introduction of a cyano group at the 2-position of an (R,S)-3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) derivative of thymine elicits selective anti-HBV activity
Journal article published in 2021 by
Shuai Tan,
Elisabetta Groaz 
,
Mark N. Prichard,
Raj Kalkeri,
Roger Ptak,
Piet Herdewijn
,
Mark N. Prichard,
Raj Kalkeri,
Roger Ptak,
Piet Herdewijn
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Abstract
The substantial impact of acyclic nucleoside phosphonates (ANPs) on human medicine encourages the synthesis of new ANP analogues with a potentially differentiated antiviral spectrum.