Published in
Royal Society of Chemistry, Chemical Communications, 17(57), p. 2180-2183, 2021
DOI: 10.1039/d0cc07824g
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Synthesis of deuterated γ-linolenic acid and application for biological studies: metabolic tuning and Raman imaging
Journal article published in 2021 by
Kosuke Dodo 
,
Ayato Sato ,
Yuki Tamura ,
Shusuke Egoshi,
Naoki Terayama ,
Koichi Fujiwara,
Kana Oonuma,
Shuhei Nakao ,
Mikiko Sodeoka
,
Ayato Sato ,
Yuki Tamura ,
Shusuke Egoshi,
Naoki Terayama ,
Koichi Fujiwara,
Kana Oonuma,
Shuhei Nakao ,
Mikiko Sodeoka
This paper is made freely available by the publisher.
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Abstract
γ-Linolenic acid (GLA) is reported to show tumor-selective cytotoxicity via unidentified mechanisms. We introduced deuterium into GLA as a dual functional tag for metabolic inhibition and Raman imaging and applied for mechanistic studies.