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Royal Society of Chemistry, RSC Medicinal Chemistry, 3(12), p. 406-409, 2021

DOI: 10.1039/d0md00337a

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Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy

Journal article published in 2021 by Koichi Sasaki ORCID, Kyohei Muguruma ORCID, Rento Osawa, Akane Fukuda, Atsuhiko Taniguchi ORCID, Akihiro Kishimura, Yoshio Hayashi ORCID, Takeshi Mori ORCID, Yoshiki Katayama ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A monocyclic Fc-binding peptide “15-Lys8Leu” enables simple preparation of a Fc-binding antibody-recruiting molecule (Fc-ARM), which induces potent cytotoxicity against folate receptor positive cancer cells via NK cell-mediated immune response.