Published in
Royal Society of Chemistry, Chemical Communications, 27(47), p. 7830, 2011
DOI: 10.1039/c1cc12228b
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A platinum Chugaev carbene complex as a potent anticancer agent
Journal article published in 2011 by
Georges Alves,
Laurent Morel,
Malika El-Ghozzi,
Daniel Avignant,
Bertrand Legeret 
,
Lionel Nauton,
Federico Cisnetti,
Arnaud Gautier
,
Lionel Nauton,
Federico Cisnetti,
Arnaud Gautier
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Abstract
A platinum Chugaev complex was synthesised and fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. This cis bis acyclic diamino carbene complex acts as a cytotoxic compound and behaves as a cisplatin equivalent by interacting with supercoiled DNA and thiols. Stability of the ligand is also discussed.