Published in
Royal Society of Chemistry, Chemical Communications, 97(48), p. 11886
DOI: 10.1039/c2cc36982f
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Clicked europium dipicolinate complexes for protein X-ray structure determination
Journal article published in 2012 by
Romain Talon,
Lionel Nauton 
,
Jean-Louis Canet,
Richard Kahn,
Eric Girard,
Arnaud Gautier
,
Jean-Louis Canet,
Richard Kahn,
Eric Girard,
Arnaud Gautier
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Abstract
New trisdipicolinic acid-lanthanide complexes are reported as phasing agents for X-ray crystallography of proteins. It is demonstrated that CuAAC modifications allow protein co-crystallization with low concentration of lanthanide complexes leading to an accurate structure determination.