Published in
Royal Society of Chemistry, Green Chemistry, 1(23), p. 37-50, 2021
DOI: 10.1039/d0gc02665d
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Route efficiency assessment and review of the synthesis of β-nucleosides via N-glycosylation of nucleobases
Journal article published in 2020 by
Felix Kaspar 
,
M. Rhia L. Stone ,
Peter Neubauer ,
Anke Kurreck
,
M. Rhia L. Stone ,
Peter Neubauer ,
Anke Kurreck
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Abstract
Instead of focusing on maximizing glycosylation yield, future syntheses of nucleosides via N-glycosylation should aim to use shorter routes, fewer protecting groups and less chromatography to achieve more efficient and sustainable processes, as this E-factor analysis reveals.