Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 1(19), p. 220-232, 2021
DOI: 10.1039/d0ob01997f
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Thiol–ene enabled preparation of S-lipidated anti-HBV peptides
Journal article published in 2020 by
Oscar A. Shepperson,
Alan J. Cameron 
,
Carol J. Wang,
Paul W. R. Harris ,
John A. Taylor,
Margaret A. Brimble
,
Carol J. Wang,
Paul W. R. Harris ,
John A. Taylor,
Margaret A. Brimble
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Abstract
Highly potent anti-HBV lipopeptides were prepared by S-lipidation using the “Cysteine Lipidation on a Peptide or Amino Acid” (CLipPA) thiol–ene reaction. Interestingly, target binding efficacy correlated poorly with inhibitory potency.