Published in
Royal Society of Chemistry, RSC Medicinal Chemistry, 1(12), p. 120-128, 2021
DOI: 10.1039/d0md00291g
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Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents
Journal article published in 2020 by
Julia Fernández de Luco 
,
Alejandro I. Recio-Balsells ,
Diego G. Ghiano,
Ana Bortolotti,
Juán Manuel Belardinelli ,
Nina Liu,
Pascal Hoffmann,
Christian Lherbet,
Peter J. Tonge ,
Babu Tekwani,
Héctor R. Morbidoni ,
Guillermo R. Labadie
,
Alejandro I. Recio-Balsells ,
Diego G. Ghiano,
Ana Bortolotti,
Juán Manuel Belardinelli ,
Nina Liu,
Pascal Hoffmann,
Christian Lherbet,
Peter J. Tonge ,
Babu Tekwani,
Héctor R. Morbidoni ,
Guillermo R. Labadie
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Abstract
A collection of 37 triazolyl-triclosan derivatives were prepared as possible antileishmanial drugs. The InhA ortholog in Leishmania donovani was proposed as a putative druggable target.