Published in
Royal Society of Chemistry, New Journal of Chemistry, 45(44), p. 19891-19901, 2020
DOI: 10.1039/d0nj02825h
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Palladium(II) complexes bearing 1-iminothiolate-3,5-dimethylpyrazoles: synthesis, cytotoxicity, DNA binding and enzymatic inhibition studies
Journal article published in 2020 by
Thales Reggiani de Moura 
,
Renan Diego Zanetti,
Débora Eduarda Soares Silva ,
Renan Farias,
Renan Lira de Farias ,
Antônio Eduardo Mauro,
José Clayston Melo Pereira,
Aline Aparecida de Souza,
Wagner Alves de Souza Júdice ,
Fábio da Silva Siqueira,
Fábio da Silva Siqueira,
Wagner Alves de Souza Judice,
Mauro Almeida Lima,
Fillipe Vieira Rocha,
Victor Marcelo Deflon
and other authors.
,
Renan Diego Zanetti,
Débora Eduarda Soares Silva ,
Renan Farias,
Renan Lira de Farias ,
Antônio Eduardo Mauro,
José Clayston Melo Pereira,
Aline Aparecida de Souza,
Wagner Alves de Souza Júdice ,
Fábio da Silva Siqueira,
Fábio da Silva Siqueira,
Wagner Alves de Souza Judice,
Mauro Almeida Lima,
Fillipe Vieira Rocha,
Victor Marcelo Deflon
and other authors.
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Abstract
This work describes the enzymatic inhibitory activity of four novel Pd(ii) complexes towards topoisomerase IIα and cathepsins B and L.In silicostudies agree well with the enhancedin vitrocathepsin B inhibition induced by compound4(58% at 10 μM).