Published in
Royal Society of Chemistry, Dalton Transactions, 43(49), p. 15219-15230, 2020
DOI: 10.1039/d0dt02612c
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Cytotoxic (cis,cis-1,3,5-triaminocyclohexane)ruthenium(II)–diphosphine complexes; evidence for covalent binding and intercalation with DNA
Journal article published in 2020 by
Dan E. Wise,
Aimee J. Gamble,
Sham W. Arkawazi 
,
Paul Howard Walton ,
M. Carmen Galan ,
Michael P. O'Hagan ,
Karen G. Hogg ,
Joanne L. Marrison,
Peter J. O'Toole,
Hazel Anne Sparkes ,
Jason Martin Lynam ,
Paul G. Pringle
,
Paul Howard Walton ,
M. Carmen Galan ,
Michael P. O'Hagan ,
Karen G. Hogg ,
Joanne L. Marrison,
Peter J. O'Toole,
Hazel Anne Sparkes ,
Jason Martin Lynam ,
Paul G. Pringle
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Abstract
New Ru complexes are described that have the potential to interact with DNA in the three ways shown and this may be the reason why some of these complexes have such high antiproliferative activity.