Published in
Royal Society of Chemistry, Journal of Analytical Atomic Spectrometry, 11(35), p. 2498-2508, 2020
DOI: 10.1039/d0ja00323a
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Sample preparation with sucrose cryoprotection dramatically alters Zn distribution in the rodent hippocampus, as revealed by elemental mapping
Journal article published in 2020 by
M. Jake Pushie 
,
Ashley Hollings ,
Juliane Reinhardt,
Samuel M. Webb ,
Virginie Lam,
Ryu Takechi,
J. C. L. Mamo ,
Phyllis G. Paterson,
Michael E. Kelly ,
Graham Neil George ,
Ingrid J. Pickering ,
Mark J. Hackett
,
Ashley Hollings ,
Juliane Reinhardt,
Samuel M. Webb ,
Virginie Lam,
Ryu Takechi,
J. C. L. Mamo ,
Phyllis G. Paterson,
Michael E. Kelly ,
Graham Neil George ,
Ingrid J. Pickering ,
Mark J. Hackett
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Abstract
Transition metal ions (Fe, Mn, Cu, Zn) are essential for healthy brain function, but common sample preparations, such as sucrose cryo-protection alter their distribution, which can confound studies of brain disease.