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Royal Society of Chemistry, Lab on a Chip, 16(20), p. 3011-3023, 2020

DOI: 10.1039/d0lc00427h

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Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca2+ signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea

Journal article published in 2020 by Flavia Mazzarda ORCID, Annunziata D'Elia ORCID, Roberto Massari ORCID, Adele De Ninno ORCID, Francesca Romana Bertani ORCID, Luca Businaro ORCID, Gaia Ziraldo ORCID, Veronica Zorzi ORCID, Chiara Nardin ORCID, Chiara Peres ORCID, Francesco Chiani ORCID, Abraham Tettey-Matey ORCID, Marcello Raspa ORCID, Ferdinando Scavizzi ORCID, Alessandro Soluri ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Using microfluidics, ATP biosensors, multiphoton microscopy and genetically targeted mice, we show that ATP release through connexin hemichannels, and not pannexin 1 channels, underlies spontaneous Ca2+ wave propagation in the greater epithelial ridge of the developing cochlea.