Published in
Royal Society of Chemistry, Nanoscale, 37(12), p. 19093-19103, 2020
DOI: 10.1039/d0nr01631d
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The Other Side of the Corona: Nanoparticles Inhibit the Protease Taspase1 in a Size-Dependent Manner
Journal article published in 2020 by
Johannes van den Boom 
,
Astrid Hensel ,
Franziska Trusch ,
Anja Matena ,
Svenja Siemer ,
Desiree Guel ,
Dominic Docter ,
Alexander Höing ,
Peter Bayer ,
Roland H. Stauber ,
Shirley K. Knauer
,
Astrid Hensel ,
Franziska Trusch ,
Anja Matena ,
Svenja Siemer ,
Desiree Guel ,
Dominic Docter ,
Alexander Höing ,
Peter Bayer ,
Roland H. Stauber ,
Shirley K. Knauer
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Abstract
Adsorption of biomolecules to nanoparticles leads to corona formation, affecting not only the nanomaterial's identity, but also protein function: Taspase1 protease activity is inhibited by silica particles in a size-dependent, noncompetitive manner.