Published in
Royal Society of Chemistry, Chemical Communications, 53(56), p. 7289-7292, 2020
DOI: 10.1039/d0cc02862b
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Trivalent Metal Complex Geometry of the Substrate Governs Cathepsin B Enzymatic Cleavage Rate.
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Abstract
The identity of the trivalent metal ion controls the rate of the enzymatic cleavage of a series of metal-complexed cathepsin B substrates. Increasing the distance between the metal complex and the enzyme cleavage site diminishes this effect.