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Royal Society of Chemistry, Organic and Biomolecular Chemistry, 21(18), p. 4000-4003, 2020

DOI: 10.1039/d0ob00972e

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Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation

Journal article published in 2020 by Robin L. Brabham ORCID, Tessa Keenan ORCID, Annika Husken, Jacob Bilsborrow ORCID, Ryan McBerney, Vajinder Kumar, W. Bruce Turnbull ORCID, Martin A. Fascione ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A genetically incorporated ThrK unnatural amino acid can undergo rapid periodate oxidation to reveal a reactive internal α-oxo aldehyde.