Published in
Royal Society of Chemistry, RSC Medicinal Chemistry, 8(11), p. 885-895, 2020
DOI: 10.1039/d0md00057d
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Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei
Journal article published in 2020 by
Zhongsheng Zhang,
Ximena Barros-Álvarez,
J. Robert Gillespie 
,
Ranae M. Ranade,
Wenlin Huang,
Sayaka Shibata,
Nora M. R. Molasky ,
Omeed Faghih,
Aisha Mushtaq,
Robert K. M. Choy ,
Eugenio de Hostos,
Wim G. J. Hol,
Christophe L. M. J. Verlinde,
Frederick S. Buckner ,
Erkang Fan
,
Ranae M. Ranade,
Wenlin Huang,
Sayaka Shibata,
Nora M. R. Molasky ,
Omeed Faghih,
Aisha Mushtaq,
Robert K. M. Choy ,
Eugenio de Hostos,
Wim G. J. Hol,
Christophe L. M. J. Verlinde,
Frederick S. Buckner ,
Erkang Fan
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Abstract
Potent T. brucei methionyl-tRNA synthetase inhibitors built on two novel short and rigid linker systems.