Published in
Royal Society of Chemistry, Reaction Chemistry and Engineering, 5(5), p. 859-864, 2020
DOI: 10.1039/d0re00067a
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Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents
Journal article published in 2020 by
Paola Vitale 
,
Francesco Lavolpe,
Francesca Valerio ,
Mariaelena Di Biase ,
Filippo Maria Perna ,
Eugenia Messina ,
Gennaro Agrimi ,
Isabella Pisano ,
Vito Capriati
,
Francesco Lavolpe,
Francesca Valerio ,
Mariaelena Di Biase ,
Filippo Maria Perna ,
Eugenia Messina ,
Gennaro Agrimi ,
Isabella Pisano ,
Vito Capriati
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Abstract
A chemo-enzymatic strategy for the preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles using a lactic acid bacterium as a whole-cell biocatalyst and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents is disclosed.