Nanofiber-based electronics with unique fibrous interlocked microstructures are capable of differentiating various mechanical stimuli, such as normal pressure, lateral strain, and bending. Skin-inspired electronics with an ultrahigh sensitivity of 71.07 kPa⁻¹ under a small applied pressure (<0.06 kPa), a rapid response time (<2 ms), and highly reproducible stability (>5000 cycles) are reported, thereby demonstrating their potential applications in versatile human–machine interfaces.