Published in
Royal Society of Chemistry, Food and Function, 4(11), p. 3271-3279, 2020
DOI: 10.1039/d0fo00089b
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Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells
Journal article published in 2020 by
Santa Cirmi 
,
Marilena Celano,
Giovanni Enrico Lombardo,
Valentina Maggisano,
Antonio Procopio ,
Diego Russo ,
Michele Navarra
,
Marilena Celano,
Giovanni Enrico Lombardo,
Valentina Maggisano,
Antonio Procopio ,
Diego Russo ,
Michele Navarra
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Abstract
The present findings demonstrate that oleacein, the main secoiridoid of extravirgin olive oil, acts against neuroblastoma cells, by reducing cell adhesion and migration, inducing apoptotic death and modulating STAT3-dependent pathway.