Published in
Royal Society of Chemistry, RSC Medicinal Chemistry, 5(11), p. 577-582, 2020
DOI: 10.1039/d0md00025f
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Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate as an HIV-1 replication inhibitor
Journal article published in 2020 by
Jeanne Fichez,
Cathia Soulie,
Laurent Le Corre,
Sophie Sayon,
Stéphane Priet 
,
Karine Alvarez,
Olivier Delelis,
Patrick Gizzi,
Guillaume Prestat ,
Christine Gravier-Pelletier ,
Anne-Geneviève Marcelin,
Vincent Calvez,
Patricia Busca
,
Karine Alvarez,
Olivier Delelis,
Patrick Gizzi,
Guillaume Prestat ,
Christine Gravier-Pelletier ,
Anne-Geneviève Marcelin,
Vincent Calvez,
Patricia Busca
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Abstract
Identified as an HIV-1 inhibitor in cellulo, this pyrazole does not belong to the three main classes of anti HIV-drugs, a feature of prime interest in the context of viral resistance.