Published in
Royal Society of Chemistry, Journal of Materials Chemistry B: Materials for biology and medicine, 23(8), p. 5026-5041, 2020
DOI: 10.1039/d0tb00340a
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Tuning of endosomal escape and gene expression by functional groups, molecular weight and transfection medium: a structure–activity relationship study
Journal article published in 2020 by
Friederike Richter,
Liam Martin,
Katharina Leer,
Elisabeth Moek,
Franziska Hausig,
Johannes C. Brendel 
,
Anja Traeger
,
Anja Traeger
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Abstract
A library of cationic polyacrylamide homopolymers was synthesized and their gene delivery, endosomal release, and interaction with endosome-specific lipids were investigated. The guanidinium-containing polymers were most efficient.