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Royal Society of Chemistry, Organic and Biomolecular Chemistry, 15(18), p. 2838-2844, 2020

DOI: 10.1039/d0ob00203h

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Direct synthesis of cyclic lipopeptides using intramolecular native chemical ligation and thiol–ene CLipPA chemistry

Journal article published in 2020 by Victor V. Yim ORCID, Iman Kavianinia ORCID, Alan J. Cameron ORCID, Paul W. R. Harris ORCID, Margaret A. Brimble ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Cyclic lipopeptides are often challenging synthetic targets. A synthetic approach is presented that employs cyclisation by intramolecular native chemical ligation (NCL) and a thiol–ene “CLipPA” reaction to afford S-lipidated analogues of iturin A.