Published in
Royal Society of Chemistry, MedChemComm, 8(10), p. 1361-1369, 2019
DOI: 10.1039/c9md00096h
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Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
Journal article published in 2019 by
Benjamin N. Atkinson 
,
David Steadman ,
Yuguang Zhao,
James Sipthorp ,
Luca Vecchia ,
Reinis R. Ruza ,
Fiona Jeganathan,
Georgie Lines,
Sarah Frew,
Amy Monaghan,
Svend Kjær,
Magda Bictash,
E. Yvonne Jones ,
Paul V. Fish
,
David Steadman ,
Yuguang Zhao,
James Sipthorp ,
Luca Vecchia ,
Reinis R. Ruza ,
Fiona Jeganathan,
Georgie Lines,
Sarah Frew,
Amy Monaghan,
Svend Kjær,
Magda Bictash,
E. Yvonne Jones ,
Paul V. Fish
This paper was not found in any repository, but could be made available legally by the author.
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Abstract
Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.