Published in
Royal Society of Chemistry, Dalton Transactions, 5(49), p. 1403-1415, 2020
DOI: 10.1039/c9dt03948a
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Organometallic ciprofloxacin conjugates with dual action: synthesis, characterization, and antimicrobial and cytotoxicity studies
Journal article published in 2020 by
Łukasz Szczupak 
,
Aleksandra Kowalczyk ,
Damian Trzybiński ,
Krzysztof Woźniak ,
Gracia Mendoza ,
Manuel Arruebo ,
Dietmar Steverding ,
Paweł Stączek ,
Konrad Kowalski
,
Aleksandra Kowalczyk ,
Damian Trzybiński ,
Krzysztof Woźniak ,
Gracia Mendoza ,
Manuel Arruebo ,
Dietmar Steverding ,
Paweł Stączek ,
Konrad Kowalski
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Abstract
Organometallic ciprofloxacin conjugates were synthesized and two mechanisms of antimicrobial activity were demonstrated. The first mechanism involves the inhibition of type IIA topoisomerases and the second involves ROS generation in bacterial cells.