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Royal Society of Chemistry, Dalton Transactions, 5(49), p. 1403-1415, 2020

DOI: 10.1039/c9dt03948a

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Organometallic ciprofloxacin conjugates with dual action: synthesis, characterization, and antimicrobial and cytotoxicity studies

Journal article published in 2020 by Łukasz Szczupak ORCID, Aleksandra Kowalczyk ORCID, Damian Trzybiński ORCID, Krzysztof Woźniak ORCID, Gracia Mendoza ORCID, Manuel Arruebo ORCID, Dietmar Steverding ORCID, Paweł Stączek ORCID, Konrad Kowalski ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Organometallic ciprofloxacin conjugates were synthesized and two mechanisms of antimicrobial activity were demonstrated. The first mechanism involves the inhibition of type IIA topoisomerases and the second involves ROS generation in bacterial cells.