Published in
Royal Society of Chemistry, Nanoscale, 4(12), p. 2452-2463, 2020
DOI: 10.1039/c9nr08714a
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Nanotoxicology at the particle/micelle frontier: influence of core-polymerization on the intracellular distribution, cytotoxicity and genotoxicity of polydiacetylene micelles
Journal article published in 2020 by
Federica Costamagna,
Hervé Hillaireau 
,
Juliette Vergnaud ,
Damien Clarisse,
Lucie Jamgotchian,
Olivier Loreau,
Stéphanie Denis,
Edmond Gravel ,
Eric Doris ,
Elias Fattal
,
Juliette Vergnaud ,
Damien Clarisse,
Lucie Jamgotchian,
Olivier Loreau,
Stéphanie Denis,
Edmond Gravel ,
Eric Doris ,
Elias Fattal
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Abstract
Non-polymerized micelles accumulate in the cell membrane inducing permeabilization and high toxicity; polymerized, particle-like micelles are internalized but exert low toxicity.