Published in
Royal Society of Chemistry, Journal of Materials Chemistry B: Materials for biology and medicine, 3(8), p. 484-491, 2020
DOI: 10.1039/c9tb01957j
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Spermine amides of selected triterpenoid acids: dynamic supramolecular system formation influences the cytotoxicity of the drugs
Journal article published in 2020 by
Uladzimir Bildziukevich 
,
Matěj Malík,
Zulal Özdemir ,
Lucie Rárová ,
Lucie Janovská,
Miroslav Šlouf ,
David Šaman,
Jan Šarek ,
Nonappa Nonappa ,
Zdeněk Wimmer
,
Matěj Malík,
Zulal Özdemir ,
Lucie Rárová ,
Lucie Janovská,
Miroslav Šlouf ,
David Šaman,
Jan Šarek ,
Nonappa Nonappa ,
Zdeněk Wimmer
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Abstract
Cytotoxicity data: 8a: IC50 [μM]: 18.8/31.8/32.6/17.2 (25.1 ± 8.2), due to the dynamic self-assembly found, low-contrast networks (TEM); 8b: IC50 [μM]: 7.5 ± 1.6, dynamic self-assembly not detected, partly helical structures (TEM).