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Journal of Rheumatology, The Journal of Rheumatology, 1(47), p. 15-19, 2019

DOI: 10.3899/jrheum.180832

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Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging

Journal article published in 2019 by Philipp Sewerin ORCID, Christoph Schleich, Ralph Brinks, Anja Müller-Lutz, Florian Fichter, Markus Eichner, Matthias Schneider, Benedikt Ostendorf, Stefan Vordenbäumen
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Objective.To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA).Methods.Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.Results.Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05).Conclusion.Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.