Published in
Royal Society of Chemistry, Nanoscale, 45(11), p. 21733-21739, 2019
DOI: 10.1039/c9nr09347h
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On the role of helper lipids in lipid nanoparticle formulations of siRNA
Journal article published in 2019 by
Jayesh A. Kulkarni 
,
Dominik Witzigmann ,
Jerry Leung ,
Yuen Yi C. Tam,
Pieter R. Cullis
,
Dominik Witzigmann ,
Jerry Leung ,
Yuen Yi C. Tam,
Pieter R. Cullis
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Abstract
In empty LNP formulations, DSPC–cholesterol resides in outer layers, whereas in loaded systems some of the DSPC–cholesterol is internalized together with siRNA.