Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 45(17), p. 9703-9707, 2019
DOI: 10.1039/c9ob02166c
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Synthesis and biological profiling of parthenolide ether analogs
Journal article published in 2019 by
Robert R. A. Freund 
,
Philipp Gobrecht,
Pascal Moser ,
Dietmar Fischer ,
Hans-Dieter Arndt
,
Philipp Gobrecht,
Pascal Moser ,
Dietmar Fischer ,
Hans-Dieter Arndt
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Abstract
Cyclic ether derivatives of parthenolide were synthesized by using two cyclization strategies, relying on 2-(silyloxy) allylboration. Characterization for tubulin carboxypeptidase inhibition generated new insights into structure–activity relationships.