Published in
Royal Society of Chemistry, Analyst, 23(144), p. 7049-7056, 2019
DOI: 10.1039/c9an01631g
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A fingerprint of amyloid plaques in a bitransgenic animal model of Alzheimer's disease obtained by statistical unmixing analysis of hyperspectral Raman data
Journal article published in 2019 by
Emerson A. Fonseca,
Lucas Lafetá,
Renan Cunha 
,
Hudson Miranda,
João Campos ,
Helton G. Medeiros,
Marco A. Romano-Silva ,
Raigna A. Silva,
Alexandre S. Barbosa,
Rafael P. Vieira ,
Leandro M. Malard ,
Ado Jorio
,
Hudson Miranda,
João Campos ,
Helton G. Medeiros,
Marco A. Romano-Silva ,
Raigna A. Silva,
Alexandre S. Barbosa,
Rafael P. Vieira ,
Leandro M. Malard ,
Ado Jorio
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Abstract
We have found different Raman signatures of AB fibrils and in brain tissues from unmixed analysis, providing a detailed image of amyloid plaques in the brain, with the potential to be used as biomarkers.