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Journal of Rheumatology, The Journal of Rheumatology, 10(46), p. 1369-1373, 2019

DOI: 10.3899/jrheum.180870

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The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography

Journal article published in 2019 by Sarah L. Manske ORCID, Scott C. Brunet ORCID, Stephanie Finzel ORCID, Kathryn S. Stok ORCID, Philip G. Conaghan ORCID, Steven K. Boyd ORCID, Cheryl Barnabe ORCID
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Abstract

Objective.We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis.Methods.In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints.Results.Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p < 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0.Conclusion.HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.