Published in
Royal Society of Chemistry, MedChemComm, 9(10), p. 1646-1655, 2019
DOI: 10.1039/c9md00234k
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Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin
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Abstract
A series of piperidine-based peptidomimetic inhibitors have been synthesized and evaluated their activity against the three serine proteases HGFA, matriptase, and hepsin. All analogs showed nanomolar activity against matriptase and hepsin.