Published in
Royal Society of Chemistry, Chemical Communications, 64(55), p. 9535-9538, 2019
DOI: 10.1039/c9cc03719e
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Activity-based protein profiling reveals that secondary-carbon-centered radicals of synthetic 1,2,4-trioxolanes are predominately responsible for modification of protein targets in malaria parasites
Journal article published in 2019 by
Chunyan Wei,
Cheng-Xiao Zhao,
Sheng Liu,
Jin-Hui Zhao,
Zi Ye,
Heng Wang,
Shi-Shan Yu,
Chong-Jing Zhang 
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Abstract
By means of rational probe design and activity-based protein profiling (ABPP), we found that the secondary-carbon-centered radical predominates in protein targeting of synthetic trioxolane in malaria parasites.