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Royal Society of Chemistry, Chemical Communications, 45(55), p. 6361-6364, 2019

DOI: 10.1039/c9cc02779c

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Ring opening of epoxides with [18F]FeF species to produce [18F]fluorohydrin PET imaging agents

Journal article published in 2019 by Stefan Verhoog ORCID, Allen F. Brooks ORCID, Wade P. Winton ORCID, Benjamin L. Viglianti ORCID, Melanie S. Sanford ORCID, Peter J. H. Scott ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

This report describes a simple technique for the preparation of [18F]HF and its application to the generation of an [18F]FeF species for opening sterically hindered epoxides. This easily automated one-pot procedure has been successfully employed to prepare four drug-like molecules in good yields and high molar activities, including 5-[18F]fluoro-6-hydroxy-cholesterol.