Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 12(17), p. 3249-3257, 2019
DOI: 10.1039/c8ob03153c
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Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability
Journal article published in 2019 by
Manabendra Das 
,
Yang Du ,
Jonas S. Mortensen ,
Manuel Ramos,
Lubna Ghani ,
Ho Jin Lee ,
Hyoung Eun Bae ,
Bernadette Byrne ,
Lan Guan ,
Claus J. Loland ,
Brian K. Kobilka ,
Pil Seok Chae
,
Yang Du ,
Jonas S. Mortensen ,
Manuel Ramos,
Lubna Ghani ,
Ho Jin Lee ,
Hyoung Eun Bae ,
Bernadette Byrne ,
Lan Guan ,
Claus J. Loland ,
Brian K. Kobilka ,
Pil Seok Chae
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Abstract
A novel class of non-chromophoric trehalose-cored amphiphiles was developed and some of the detergents displayed favorable behavior in stabilizing membrane proteins.