Published in
Royal Society of Chemistry, Nanoscale, 18(11), p. 9023-9031, 2019
DOI: 10.1039/c9nr02004g
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Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads
Journal article published in 2019 by
Jayesh A. Kulkarni 
,
Dominik Witzigmann ,
Jerry Leung ,
Roy van der Meel ,
Josh Zaifman,
Maria M. Darjuan,
Hiu Man Grisch-Chan ,
Beat Thöny ,
Yuen Yi C. Tam,
Pieter R. Cullis
,
Dominik Witzigmann ,
Jerry Leung ,
Roy van der Meel ,
Josh Zaifman,
Maria M. Darjuan,
Hiu Man Grisch-Chan ,
Beat Thöny ,
Yuen Yi C. Tam,
Pieter R. Cullis
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Abstract
Neutralization of the pH (and ionizable lipid) drives the fusion of precursor vesicles into the electron-dense core structures attributed to lipid nanoparticles.