Published in
Royal Society of Chemistry, New Journal of Chemistry, 17(43), p. 6615-6621, 2019
DOI: 10.1039/c9nj00766k
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Experimental and computational studies on the synthesis of diastereoselective natural-based Meldrum spiro dibenzofuran derivatives
Journal article published in 2019 by
Parvaneh Dastoorani,
Mohammad A. Khalilzadeh 
,
Fatemeh Khaleghi ,
Malek Taher Maghsoodlou,
Werner Kaminsky ,
Ali Shokuhi Rad
,
Fatemeh Khaleghi ,
Malek Taher Maghsoodlou,
Werner Kaminsky ,
Ali Shokuhi Rad
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Abstract
Herein, a novel route to achieve chiral Meldrum spiro dibenzofuran derivatives was developed, which involved a 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid)-mediated Knoevenagel reaction of substituted aryl halides, followed by a Diels–Alder reaction with euparin as a natural compound.