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Royal Society of Chemistry, Journal of Analytical Atomic Spectrometry, 4(34), p. 708-715, 2019

DOI: 10.1039/c8ja00386f

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Development of a method for the quantitative metabolite profiling of pharmaceutical drugs using HPLC-ICP-MS following pre-column derivatization of their amino and hydroxyl groups using 4-aminopyridine as a model compound

Journal article published in 2019 by Sanwang Li ORCID, Filip Cuyckens ORCID, Frederic Lynen ORCID, Frank Vanhaecke ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Presence of amino and/or hydroxyl groups allows for derivatization of APIs and their metabolites with 4-iodobenzoylchloride, thus enabling HPLC-ICP-MS metabolite profiling.