Published in
Royal Society of Chemistry, Journal of Materials Chemistry B: Materials for biology and medicine, 9(7), p. 1503-1509, 2019
DOI: 10.1039/c8tb03188f
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Nanomized tumor-microenvironment-active NIR fluorescent prodrug for ensuring synchronous occurrences of drug release and fluorescence tracing
Journal article published in 2019 by
Qiang Li,
Jun Cao,
Qi Wang 
,
Jie Zhang,
Shiqin Zhu,
Zhiqian Guo,
Wei-Hong Zhu
,
Jie Zhang,
Shiqin Zhu,
Zhiqian Guo,
Wei-Hong Zhu
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Abstract
A nanomized NIR fluorescent prodrug was developed with improved bioavailability and tumor-targeting ability. Nanomized tumor-microenvironment-active NIR DCM-S-GEM/PEG prodrug provides a novel approach to realize long real-time tracking of drug delivery and activation process without systemic toxicity in vivo.