Published in
Royal Society of Chemistry, MedChemComm, 2(10), p. 310-314, 2019
DOI: 10.1039/c8md00477c
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Identification of the first enantiopure Rac1–Tiam1 protein–protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed hydroarylation
Journal article published in 2019 by
Alessandro Ruffoni 
,
Nicola Ferri ,
Andrea Pinto ,
Sara Pellegrino ,
Alessandro Contini ,
Francesca Clerici
,
Nicola Ferri ,
Andrea Pinto ,
Sara Pellegrino ,
Alessandro Contini ,
Francesca Clerici
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Abstract
The remote substituent regiocontrol of phosphine free Heck hydroarylation has been exploited for the preparation of the first enantiopure inhibitor of Rac1–Tiam1 PPI.