Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 35(12), p. 6794-6799, 2014
DOI: 10.1039/c4ob00915k
Links
- ORCID
- ORCID
- ORCID
- Royal Society of Chemistry
- [eprints.whiterose.ac.uk]
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [eprints.whiterose.ac.uk] | PDF
Tools
Orthogonal functionalisation of α-helix mimetics
Journal article published in 2014 by
Anna Barnard,
Kérya Long,
David J. Yeo,
Jennifer A. Miles 
,
Valeria Azzarito,
George M. Burslem ,
Panchami Prabhakaran,
Thomas A. Edwards,
Andrew J. Wilson
,
Valeria Azzarito,
George M. Burslem ,
Panchami Prabhakaran,
Thomas A. Edwards,
Andrew J. Wilson
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.