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American Association for the Advancement of Science, Science Translational Medicine, 479(11), 2019

DOI: 10.1126/scitranslmed.aaq1427

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IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Journal article published in 2019 by Felipe J. Núñez ORCID, Flor M. Mendez, Padma Kadiyala, Mahmoud S. Alghamri ORCID, Masha G. Savelieff ORCID, Maria B. Garcia-Fabiani, Santiago Haase, Carl Koschmann, Anda-Alexandra Calinescu ORCID, Neha Kamran, Meghna Saxena, Rohin Patel, Stephen Carney ORCID, Marissa Z. Guo, Marta Edwards and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Mutant IDH1 coexpressed with inactivating TP53 and ATRX mutations in glioma enhances DNA repair, causing resistance to genotoxic therapies.