Royal Society of Chemistry, Organic and Biomolecular Chemistry, 27(15), p. 5656-5668, 2017
DOI: 10.1039/c7ob01058c
Full text: Unavailable
Heparan sulfate is ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These negatively-charged carbohydrate chains play essential roles in many important cellular functions by interacting with various heparan sulfate binding proteins (HSBP). This review discusses methods for targeting these complex biomolecules, as strategies for treating human disease.