Published in
Royal Society of Chemistry, Chemical Communications, 73(54), p. 10312-10315, 2018
DOI: 10.1039/c8cc05755a
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Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding
Journal article published in 2018 by
Giuseppina De Simone 
,
Andrea Angeli ,
Murat Bozdag ,
Claudiu T. Supuran ,
Jean-Yves Winum ,
Simona Maria Monti ,
Vincenzo Alterio
,
Andrea Angeli ,
Murat Bozdag ,
Claudiu T. Supuran ,
Jean-Yves Winum ,
Simona Maria Monti ,
Vincenzo Alterio
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Abstract
N-Unsubstituted carbamates can be used as lead compounds for the development of carbonic anhydrase inhibitors possessing a binding mode similar to bicarbonate.