Published in
American Chemical Society, Journal of Medicinal Chemistry, 18(61), p. 8226-8240, 2018
DOI: 10.1021/acs.jmedchem.8b00690
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Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)
Journal article published in 2018 by
Hannah L. Woodward 
,
Paolo Innocenti,
Kwai-Ming J. Cheung,
Angela Hayes,
Jennie Roberts,
Alan T. Henley,
Amir Faisal,
Grace Wing-Yan Mak,
Gary Box,
Isaac M. Westwood,
Nora Cronin,
Michael Carter,
Melanie Valenti,
Alexis De Haven Brandon,
Lisa O’Fee
and other authors.
,
Paolo Innocenti,
Kwai-Ming J. Cheung,
Angela Hayes,
Jennie Roberts,
Alan T. Henley,
Amir Faisal,
Grace Wing-Yan Mak,
Gary Box,
Isaac M. Westwood,
Nora Cronin,
Michael Carter,
Melanie Valenti,
Alexis De Haven Brandon,
Lisa O’Fee
and other authors.
This paper is made freely available by the publisher.
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