Published in
Royal Society of Chemistry, MedChemComm, 9(8), p. 1850-1855
DOI: 10.1039/c7md00278e
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4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade
Journal article published in 2017 by
Agnese C. Pippione 
,
Antonella Federico ,
Alex Ducime ,
Stefano Sainas ,
Donatella Boschi ,
Alessandro Barge ,
Elisa Lupino ,
Marco Piccinini ,
Michael Kubbutat ,
Jean-Marie Contreras ,
Christophe Morice ,
Salam Al-Karadaghi ,
Marco L. Lolli
,
Antonella Federico ,
Alex Ducime ,
Stefano Sainas ,
Donatella Boschi ,
Alessandro Barge ,
Elisa Lupino ,
Marco Piccinini ,
Michael Kubbutat ,
Jean-Marie Contreras ,
Christophe Morice ,
Salam Al-Karadaghi ,
Marco L. Lolli
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Abstract
Compound 4, derived from IMD-0354, blocks the canonical NF-κB pathway although it is inactive on the IKKβ enzyme.