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Royal Society of Chemistry, MedChemComm, 6(9), p. 963-968

DOI: 10.1039/c8md00068a

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N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

Journal article published in 2018 by Agnese C. Pippione ORCID, Stefano Sainas ORCID, Antonella Federico, Elisa Lupino ORCID, Marco Piccinini ORCID, Michael Kubbutat ORCID, Jean-Marie Contreras, Christophe Morice ORCID, Alessandro Barge ORCID, Alex Ducime ORCID, Donatella Boschi ORCID, Salam Al-Karadaghi ORCID, Marco L. Lolli ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Resulting from hit-to-lead optimization, the aminopyrazole3ais a NIK inhibitor selective over 44 kinases.