Published in
Royal Society of Chemistry, Chemical Communications, 74(52), p. 11151-11154
DOI: 10.1039/c6cc05565f
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“Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry
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Abstract
A new self-healing hydrogel is developed using dynamic coordinate bonds between drug loaded MgSiO3 nanoparticles and bisphosphonate functionalized hyaluronic acid. The nanocomposite network is stable at neutral pH, but is disassembled in an acidic environment, providing “smart” drug release.