Published in
Royal Society of Chemistry, Dalton Transactions, 5(46), p. 1559-1566
DOI: 10.1039/c6dt03749f
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Cisplatin and valproate released from the bifunctional [Pt(IV)Cl2(NH3)2(valproato)2] antitumor prodrug or from liposome formulations: who does what?
Journal article published in 2017 by
M. Ravera 
,
E. Gabano ,
I. Zanellato ,
A. Gallina,
E. Perin,
A. Arrais ,
S. Cantamessa,
D. Osella
,
E. Gabano ,
I. Zanellato ,
A. Gallina,
E. Perin,
A. Arrais ,
S. Cantamessa,
D. Osella
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Abstract
Comparison between the antiproliferative properties of a Pt(iv)-valproato complex and its metabolites indicates that the former is more active because it is unremoved from cells.